For moderate to severe rheumatoid arthritis (RA)

< 1/2 Click for additional indications >

Indication/Usage

Adult Rheumatoid Arthritis (RA):
ORENCIA® (abatacept) is a prescription medicine that reduces signs and symptoms in adults with moderate to severe RA, including those who have not been helped enough by other medicines for RA. ORENCIA may prevent further damage to your bones and joints and may help your ability to perform daily activities. In adults, ORENCIA may be used alone or with other RA treatments other than tumor necrosis factor (TNF) antagonists.

ORENCIA reduces signs and symptoms in children and adolescents 6 years of age and older with moderate to severe polyarticular JIA. ORENCIA may be used alone or with methotrexate (MTX).

X Close

For Healthcare Professionals

Preparing for Your Next Appointment

How to talk to your rheumatologist

Your doctor is your most helpful resource when facing rheumatoid arthritis (RA).
Heading to your appointment educated and prepared can ensure an open
and
productive conversation.


What to discuss with your doctor to help determine the appropriate care for your moderate to
severe RA

  • Important activities that you have been unable to do because of the pain and swelling of your RA (eg, cook for your family, put groceries away, get the kids ready for school, twist open bottles, button your shirt, climb stairs)
  • The amount of time your morning joint stiffness usually lasts
  • The level of your joint pain
  • The medications that you are currently receiving and any side effects you have been experiencing while taking them
  • Everyday activities that you struggle with (eg, shaving, getting dressed, opening bottles, turning keys)

Questions to ask yourself before your next appointment.

  • Is my current treatment helping me enough?
  • Do I struggle too much with my daily tasks?
  • How is my RA progressing?

What to ask your doctor about your RA
and ORENCIA® (abatacept)?

  • Is my current treatment working for me?
  • Is ORENCIA an appropriate option for me?
  • How is ORENCIA different from other
    treatment options?
  • When should I schedule a follow-up appointment?

Selected Important Safety Information

ORENCIA can cause serious side effects including:

Respiratory problems in patients with COPD. You may get certain respiratory problems more often if you receive ORENCIA and have COPD, including: worsened COPD, cough, or trouble breathing.


How to plan for what comes after your appointment

Before you leave your rheumatologist’s office, make sure you know what happens next in your RA treatment plan.

Keep track of how you are feeling after your appointment to determine if you need a follow-up appointment and talk to your doctor about setting expectations and goals for your treatment plan.

Sign up for ORENCIA On Call

ORENCIA On Call™.

If you are prescribed ORENCIA, be sure to sign up for
ORENCIA On Call, a free service
that pairs you with an ORENCIA Care Counselor to help you navigate your journey with
moderate to severe RA. Benefits include*:

  • 24/7 access to support from your ORENCIA Care Counselor and nurse
  • Tips and tools that may help you manage
    your RA and communicate with your support team—family, rheumatologist, friends, caregivers, and others
  • Information about co-pay assistance and help understanding insurance coverage for ORENCIA
  • Welcome packs and educational videos about ORENCIA SC (subcutaneous) and ORENCIA IV (intravenous)

Sign up for ORENCIA On Call today

Learn more

*Terms and Conditions apply.

ORENCIA nurses cannot provide personal medical advice. Your doctor is the best source of information about your health. Nurses are available Monday through Friday from 8 AM to 8 PM EST. At all other times, nurses will usually return calls within 30 to 60 minutes.


Download the Talking With Your Doctor Guide

To make the most of your doctor appointment, download Talking With Your Doctor Guide. This guide will help you and your doctor have a meaningful conversation about your moderate to severe
RA and your treatment options.

ORENCIA® Talking With Your Doctor Guide

Download the Talking
With Your Doctor Guide

 

Selected Important Safety Information

ORENCIA can cause serious side effects including:

Important Safety Information

Serious infections. ORENCIA can make you more likely to get infections or make the infection that you have get worse. Some patients have died from these infections. Call your healthcare provider immediately if you feel sick or get any of the following signs of infection: fever; feel very tired; cough; feel flu-like; or warm, red or painful skin.

Allergic reactions. Allergic reactions can happen to people who use ORENCIA. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction, which may include hives; swollen face, eyelids, lips, or tongue; or trouble breathing.

Vaccinations. You should not receive ORENCIA with certain types of vaccines. ORENCIA may cause some vaccinations to be less effective.

Hepatitis B infection. If you are a carrier of the hepatitis B virus (a virus that affects the liver), the virus can become active while you use ORENCIA. Your healthcare provider may do a blood test before you start or while using ORENCIA.

Cancer (malignancies). Certain kinds of cancer have been reported in patients receiving ORENCIA. It is not known if ORENCIA increases your chance of getting certain kinds of cancer.

Inform your healthcare provider of the following, before you receive treatment with ORENCIA® (abatacept):

Infections: If you have any kind of infection even if it is small (such as an open cut or sore), an infection that is in your whole body (such as the flu), an infection that will not go away, or a history of infections that keep coming back. ORENCIA may make your immune system less able to fight infections, so you may be more likely to get infections or any infection you have may get worse.

Tuberculosis: If you have had tuberculosis (TB), a positive skin test for TB, or if you recently have been in close contact with someone who has had TB. If you get any of the symptoms of TB (a cough that does not go away, weight loss, fever, night sweats), call your healthcare provider right away. Before you start ORENCIA, your healthcare provider may examine you for TB or perform a skin test.

If you have or have had Viral Hepatitis. Before you use ORENCIA, your healthcare provider may examine you for hepatitis.

If you have a history of Chronic Obstructive Pulmonary (lung) Disease (COPD).

If you are scheduled to have Surgery.

Allergies to the Ingredients of ORENCIA: The ingredients of intravenous (IV) ORENCIA are: abatacept, maltose, monobasic sodium phosphate, and sodium chloride for administration. The ingredients of subcutaneous (SC) ORENCIA are: abatacept, sucrose, poloxamer 188, monobasic sodium phosphate monohydrate, dibasic sodium phosphate anhydrous, and water for injection.

Vaccinations: If you have recently received a vaccination or are scheduled for any vaccination. If you are receiving ORENCIA, and for 3 months after you stop receiving ORENCIA, you should not take live vaccines.

Diabetes: If you have diabetes and use a blood glucose monitor to check your sugar levels. The infusion of ORENCIA contains maltose, a sugar that can give falsely high blood glucose readings with some monitors on the day you receive your infusion. Your healthcare provider may tell you to use a different way to monitor your blood sugar levels. ORENCIA for SC injection does not contain maltose; therefore, you do not need to change the way you monitor your blood sugar if you are taking ORENCIA subcutaneously.

Pregnancy: If you are pregnant, planning to become pregnant, or are thinking about becoming pregnant. It is not known if ORENCIA can harm your unborn baby.

Breastfeeding: You will need to decide to either breastfeed or receive treatment with ORENCIA, but not both.

If you Take Any Other Kinds of Medicine, including prescription and nonprescription medicines, vitamins, and herbal supplements.

If you are Taking Other Biologic Medicines to Treat RA or JIA such as: Enbrel® (etanercept), Humira® (adalimumab), Remicade® (infliximab), Kineret® (anakinra), Rituxan® (rituximab), Simponi® (golimumab), Cimzia® (certolizumab pegol), or Actemra® (tocilizumab). You may have a higher chance of getting a serious infection if you take ORENCIA with other biologic medicines.

Possible Side Effects of ORENCIA

ORENCIA can cause serious side effects including:

  • Serious infections. ORENCIA can make you more likely to get infections or make the infection that you have get worse. Some patients have died from these infections. Call your healthcare provider immediately if you feel sick or get any of the following signs of infection: fever; feel very tired; cough; feel flu-like; or warm, red or painful skin.
  • Allergic reactions. Allergic reactions can happen to people who use ORENCIA. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction, which may include hives; swollen face, eyelids, lips, or tongue; or trouble breathing.
  • Hepatitis B infection. If you are a carrier of the hepatitis B virus (a virus that affects the liver), the virus can become active while you use ORENCIA. Your healthcare provider may do a blood test before you start or while using ORENCIA.
  • Vaccinations. You should not receive ORENCIA with certain types of vaccines. ORENCIA may cause some vaccinations to be less effective.
  • Respiratory problems in patients with COPD. You may get certain respiratory problems more often if you receive ORENCIA and have COPD, including: worsened COPD, cough, or trouble breathing.
  • Cancer (malignancies). Certain kinds of cancer have been reported in patients receiving ORENCIA. It is not known if ORENCIA increases your chance of getting certain kinds of cancer.

Common side effects with ORENCIA are headache, upper respiratory tract infection, sore throat, and nausea. Other side effects in children and adolescents may include diarrhea, cough, fever, and abdominal pain.

Note concerning ORENCIA SC: It is not known if ORENCIA for SC injection is safe and effective in children under 18 years of age.

Please click here to read the Patient Information in the Full Prescribing Information.

This website is best viewed using the vertical display on your mobile device.

This website is best viewed using the horizontal display on your tablet device.

You are now leaving this site

You are now leaving this Bristol-Myers Squibb site.

You are about to leave this Bristol-Myers Squibb Company site. You are being redirected to another Bristol-Myers Squibb Company site. Would you like to leave this site?

You are now leaving this Bristol-Myers Squibb site.

This Internet site may provide links or references to other sites. Bristol-Myers Squibb has no responsibility for the content of such other sites and is not liable for any damages or injury arising from that content. Any links to other sites are provided merely as a convenience to the users of
this Internet site.

close

Select document
to view or download

Talking With Your Doctor Guide (PDF).

Full Prescribing Information (PDF).

If you need Adobe® Reader®, click the link below to download the free reader. Link to Adobe Reader Download page